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INFLUENZA ( 2009 H1N1) SCIENTIFIC AND MEDICAL RESOURCES

Influenza ( 2009 H1N1 ) 

Scientific & Medical Resources

Swine Flu, Influenza A, 2009 H1N1 , Pandemic, Medical, Scientific, links, medical journals, sites, videos, RSS feeds, original research papers

This knol has been created to provide a single source of all the medical and scientific advances with live RSS feeds, Video and direct links to all the original papers and biomedical advances in the fight against the Pandemic.

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Krishan Maggon

Consultant Pharmaceutical Biotechnology R&D & Advisor
Geneva, Switzerland & New York, USA
Salim Djelouat
Salim Djelouat
Professor Medical Analyses and Medical bacteriology / Scientific Author / knolAuteur
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Infographiste 2D & 3D, Webmaster, Belgique
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Serving the publishing aspirations of Knol writers, Planet Earth
CDC Transmission Electron Micrograph of H1N1 Virus
CDC PHIL  00528
 
References, sources and updates:     
All the articles, alerts and RSS feeds google, dealing with Swine Flu [Influenza A (H1N1)v] Pandemic and Reviews


Influenza A ( 2009 H1N1 ) Pandemic   FDA Advisory

Consumers are strongly urged and warned not to buy or order any  medicine or vaccine from web and internet sites.
About 50 websites were warned by the FDA to remove or delete unapproved products to diagnose,treat or prevent H1N1 Influenza or Swine Flu. The products with false claims included shampoo, dietary supplements, spray with ionic silver, gloves, unapproved diagnostic tests and electronic energy device. These products were considered illegal by the FDA and are a significant threat to public health.
Text: Beware of H1N1 Fraudulent Products: More

Talk about organic content!
Click here to try Google's latest
tool on the topic of Swine Flu.
Very COOL timeline, too.

[Ways to produce a flu vaccine chart]
WHO.
Clinical management of human infection with new influenza A (H1N1) virus: initial guidance. www.who.int/csr/.../clinical_managementH1N1_21_May_2009.pdf


Influenza A ( 2009 H1N1 ) Pandemic Official Alerts, Advisory 

 

Multilingual
WHO in Arabic, Chinese, English, French, Russian, Spanish

Pandemic (H1N1) 2009
Recommended use of antivirals
21 August 2009

Call to action
17 August 2009

Situation updates
(Last update 21 August 2009)
EMEA European Medicines Agency
Health Canada    English, French
Switzerland  French, German, Italian, English
UK
France
Info’ pandémie grippale
USA
CDC, English, Spanish

CDC H1N1 Flu Updates
2009 Flu Info
Get flu guidance for institutions of higher education
CDC Advisors Make Recommendations for Use of Vaccine Against Novel H1N1. http://www.cdc.gov/media/pressrel/2009/r090729b.htm






   CDC, FDA, ECDC ,EMEA  Direct Links



Be Healthy! Visit www.cdc.gov Centers for Disease Control (CDC)
 

2009 H1N1 Flu

Site last updated December 28, 2:00 PM ET

Situation Update

The weekly activity update is being provided one day early due to the Federal Holiday on Friday.
Map of flu activity in the U.S.Flu activity continued to decline in the United States during the week of December 13-19, 2009, as reported in FluView. The number of states reporting widespread flu activity decreased from 11 to 7. Visits to doctors for influenza-like illness, flu-associated hospitalizations, and flu-associated deaths all declined from the previous week.   Flu is unpredictable and activity can rise and fall throughout the season, but flu is is likely to continue for months caused by either 2009 H1N1 viruses or regular seasonal flu viruses. In addition to seasonal flu vaccine, a vaccine against the 2009 H1N1 virus has been produced and is the best way to protect against the pandemic virus. Supplies of this vaccine are increasing and many places have opened up vaccination to anyone who wants it. Find a vaccine.

General Information

More

Vaccination

More

Other 2009 H1N1 Flu Topics

Diagnosis
How the illness is diagnosed, recommendations for lab testing…
Infection Control
Healthcare guidance, occupational safety, facemasks & respirators…
Antivirals/Treatment
Use of Tamiflu and Relenza for treatment or prevention of H1N1 flu…
Emergency Use Authorization
Info about CDC-requested & FDA-issued EUA drugs & devices…

What You Can Do to Stay Healthy

  • Get vaccinated. Vaccination is the best protection we have against flu.Seasonal flu vaccine is available now and initial doses of 2009 H1N1 flu vaccine also are available, with additional doses available later this year.
  • Influenza is thought to spread mainly person-to-person through coughing or sneezing of infected people.
  • Take everyday actions to stay healthy.
    • Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it.
    • Wash your hands often with soap and water. If soap and water are not available, use an alcohol-based hand rub.
    • Avoid touching your eyes, nose and mouth. Germs spread that way.
    • Stay home if you get sick. CDC recommends that you stay home from work or school and limit contact with others to keep from infecting them.
  • Follow public health advice regarding school closures, avoiding crowds and other social distancing measures.
  • Stay informed. This website will be updated regularly as information becomes available.
  • Call 1-800-CDC-INFO for more information.

Info for Specific Groups

More

Free Resources

Brochures
Flyers
Podcasts
Other Resources
More

Additional Resources

For CDC Info, Text 'Health' to 87000. www.flu.gov Follow CDC Experts on WebMD's Flu Blog – Visit NowExternal Web Site Icon
Contact Us:
  • Centers for Disease Control and Prevention
    1600 Clifton Rd
    Atlanta, GA 30333
  • 800-CDC-INFO
    (800-232-4636)
    TTY: (888) 232-6348
    24 Hours/Every Day
  • cdcinfo@cdc.gov

Site last updated December 11, 3:00 PM ET
Dec 1 ALERT: Fraudulent emails referencing CDC-sponsored State Vaccination Program »

Situation Update

Map of flu activity in the U.S.During the week of November 29-December 5, 2009, flu activity continued to decline in the United States as reported in FluView. The number of states reporting widespread flu activity decreased from 25 to 14. Visits to doctors for influenza-like illness and flu-associated hospitalizations declined from the previous week, however flu-associated deaths increased.
See More On Key Flu Indicators »

General Information

More

Vaccination

More

Other 2009 H1N1 Flu Topics

Diagnosis
How the illness is diagnosed, recommendations for lab testing…
Infection Control
Healthcare guidance, occupational safety, facemasks & respirators…
Antivirals/Treatment
Use of Tamiflu and Relenza for treatment or prevention of H1N1 flu…
Emergency Use Authorization
Info about CDC-requested & FDA-issued EUA drugs & devices…

What You Can Do to Stay Healthy

  • Get vaccinated. Vaccination is the best protection we have against flu. Seasonal flu vaccine is available now and initial doses of 2009 H1N1 flu vaccine also are available, with additional doses available later this year.
  • Influenza is thought to spread mainly person-to-person through coughing or sneezing of infected people.
  • Take everyday actions to stay healthy.
    • Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it.
    • Wash your hands often with soap and water. If soap and water are not available, use an alcohol-based hand rub.
    • Avoid touching your eyes, nose and mouth. Germs spread that way.
    • Stay home if you get sick. CDC recommends that you stay home from work or school and limit contact with others to keep from infecting them.
  • Follow public health advice regarding school closures, avoiding crowds and other social distancing measures.
  • Stay informed. This website will be updated regularly as information becomes available.
  • Call 1-800-CDC-INFO for more information.

Info for Specific Groups

More

Free Resources

Brochures
Flyers
Podcasts
Other Resources
More

Additional Resources

For CDC Info, Text 'Health' to 87000. www.flu.gov Follow CDC Experts on WebMD's Flu Blog – Visit NowExternal Web Site Icon
Contact Us:
  • Centers for Disease Control and Prevention
    1600 Clifton Rd
    Atlanta, GA 30333
  • 800-CDC-INFO
    (800-232-4636)
    TTY: (888) 232-6348
    24 Hours/Every Day
  • cdcinfo@cdc.gov
Swine Flu Info
Quick Question
Are these search results helpful to you? Why or why not?
Thank you for helping us improve our site.
 

FDA 2009 H1N1 (Swine) Flu Page

The FDA plays a vital role on the team led by the U.S. Department of Health and Human Services in the fight against the 2009 H1N1 virus. The agency works closely with the Centers for Disease Control and Prevention, National Institutes of Health, other federal government agencies, and global partners such as the World Health Organization and foreign governments to protect public health during the 2009 H1N1 pandemic.
Topics on this Page:

Spotlight

H1N1 Flu Vaccine 

FDA ensures the safety, effectiveness and supply of the H1N1 flu vaccine.
Back to Top

Consumer Protection: Fraudulent H1N1 Claims and Bogus H1N1 Products 

FDA tracks and prosecutes advertisers who make fraudulent claims in ads about preventing or treating the H1N1 virus.

H1N1 Fraudulent Products


Back to Top

Antiviral Drugs 

FDA ensures the safety, effectiveness and supply of flu antiviral drugs.
Back to Top

Diagnostic Tests 

FDA approves diagnostic tests for laboratories, clinics and doctor’s offices.
Back to Top

Safety of the Food Supply 

FDA ensures the safety of the food supply.
Back to Top

Safety of the Blood Supply 

Back to Top

Supply of Masks, Gloves and Other Personal Protective Equipment 

FDA monitors the supply of facemasks, respirators and other personal protective equipment.
Back to Top
2009 Flu Info
Gripe 2009 Info
    
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 ECDC logoEuropean Center for Disease Prevention and Control
Pandemic (H1N1) 2009 


ECDC has been continuously monitoring the pandemic and regularly updates its risk assessment. This has shown that after transmitting at variable rates over the summer the pandemic is now accelerating in most European countries and all the indications are that this pandemic will be a highly significant event for Europe.
We know that risk groups; people with significant underlying health conditions, pregnant women and young children are especially affected by the virus, but the risk extends to other entirely healthy people. While many people may experience only a mild illness there are many, including young healthy individuals, who will develop severe disease and may die.
EU citizens should continue to take appropriate preventative measures e.g. personal hygiene measures. Vaccines are becoming available across the EU and national vaccination programmes are starting. Given the significant risks to health from the pandemic ECDC would strongly advise all those Europeans who are offered the vaccine to be vaccinated. By being vaccinated you protect not just your own health, but that of the people around you. 
Vaccination is always an emotive issue and EU citizens rightly require assurance that vaccines are both safe and effective. Influenza vaccines have been used for more than 60 years and have one of the best record of safety in all age groups. ECDC expects the influenza (H1N1) 2009 vaccine to have a similar safety profile as seasonal flu and we will continuously monitor their application across the EU to ensure the most up to date information is available to all.

 Zsuzsanna Jakab, ECDC Director

EUROPE MAPS

Intensity of influenza A(H1N1)v activity in EU and EFTA countries

Click on the map to enlarge the picture
 Reported cumulative number of confirmed fatal cases of influenza A(H1N1)v in EU and EFTA countries
Number of confirmed deaths among pandemic (H1N1) 2009 influenza cases by week of notification in EU and EFTA countries.
Number of confirmed deaths among pandemic (H1N1) 2009 influenza cases - week 46

MOST RECENTLY UPDATED DOCUMENTS

Daily update - Pandemic H1N1 2009 (14/12/2009)
Global Health Security Initiative: statement concerning pandemic and vaccination; EpiSouth update: several countries in the region still showing high or medium level influenza activity; Weekly influenza surveillance overview: In the majority of countries influenza activity is widespread but thirteen countries have reported decreasing rates of influenza-like illness for at least the last two weeks; A total of 1 333 fatal cases in Europe and EFTA countries and 9 530 in the rest of the world have been reported up to date.
Read more...
Daily update - Pandemic H1N1 2009 (11/12/2009)
Weekly Influenza Surveillance Overview to be published today; Eurosurveillance updates published; A total of 1 227 fatal cases in Europe and EFTA countries and 9 340 in the rest of the world have been reported up to date.
Read more...
Daily update - Pandemic H1N1 2009 (10/12/2009)
Draft WHO influenza global public health research agenda 2009-10 published. A total of 1 147 fatal cases in Europe and EFTA countries and 9 255 in the rest of the world have been reported up to date.
Read more...
Daily update - Pandemic H1N1 2009 (09/12/2009)
Germany considering sales or donations of surplus pandemic vaccine stock. ECDC describes new clinical management guidance of human pandemic infections produced by WHO and discusses the public health measures that could minimise the impact of pandemic. A total of 1 084 fatal cases in Europe and EFTA countries and 8 990 in the rest of the world have been reported up to date.
Read more...
Daily update - Pandemic H1N1 2009 (08/12/2009)
Updates from U.S.A. and Canada included Updates from Moldova, Ukraine, Belarus and Russia included; CIDRAP launches promising practices database; A total of 1 079 fatal cases in Europe and EFTA countries and 8 892 in the rest of the world have been reported up to date
Read more...
View all items

INFORMATION

Pandemic Preparedness

Note

Due to the rapidly evolving situation, documents issued by ECDC and postings on the website before 10 June 2009 contained variations when referring to the newly emerged influenza A( H1N1) virus. As of 10 June 2009 the name for the virus used in ECDC's communications is influenza A(H1N1)v, ‘v’ standing for variant.

      




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EXTERNAL LINKS


Pandemic (H1N1) 2009

A man walking with a suitcase and a shoulder bag.
WHO/Christopher Black
In focus: Travel
In this period of more frequent travel, there is no scientific reason to delay international travel to reduce spread of pandemic influenza infection. However, if you are ill it is prudent to delay travel.
:: Frequently asked questions about travel

FREQUENTLY ASKED QUESTIONS

Vaccines for pandemic influenza A (H1N1)

Antiviral drugs and pandemic (H1N1) 2009

Complete list of FAQsGUIDANCE DOCUMENTS

For national authorities

Complete list by category

PERIODICALS

Weekly Epidemiological Record
Articles on pandemic influenza 		WHAT'S NEW
Gathering vital evidence on pandemic influenza
Laboratory work in the WHO European Region
BRIEFING NOTES

WHO use of advisory bodies in responding to the influenza pandemic
3 December 2009
Oseltamivir resistance in immunocompromised hospital patients
2 December 2009
Archives of briefing notesSITUATION UPDATES

Pandemic (H1N1) 2009 - update 78
11 December 2009
Full list of updates

MEDIA CENTRE

For more information, call the special media telephone line:
+41 22 791 5000
Virtual press briefings

Centre for Strategic Health Operations (SHOC)
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REGIONAL INFORMATION ON PANDEMIC (H1N1) 2009

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WHO Eastern Mediterranean Region

WHO European Region

WHO South-East Asia Region

WHO Western Pacific Region

MORE INFORMATION

Meeting reports

Statements

Related links



Contacts | E-mail scams | Employment | FAQs | Feedback | Privacy | RSS feeds
© WHO 2009 
Industry Response to Influenza A (H1N1) Pandemic
 
 
 
Sanofi Aventis

Top Medical Journals Influenza A (H1N1)  Pandemic  Resources
( frequently includes free content original article online library)

J.S. Brownstein, C.C. Freifeld, and L.C. Madoff (2009) Influenza A (H1N1) Virus, 2009 - Online Monitoring, New England Journal of Medicine
http://www.lancet.com/H1N1-flu

BMJ Group Pandemic Flu

   Medical and Scientific Sources 

CDC PHIL ID 11214 Transmission Electron Micrograph of H1N1 Virus


New England Journal of Medicine Influenza Center


















 
The Lancet, Elsevier Global Medical News


            ·                       International Team Details H1N1 Concerns for Hajj Pilgrims

Note: the following listings are undergoing link repair



British Medical Journal (BMJ) Group

   BMJ discusses PloS Currents and knols with most PVs




   What these Knols
Tell Us...
By Krishan Maggon


Host Dependent Evolutionary Patterns and the Origin of 2009 H1N1 Pandemic Influenza
By Alexander Solovyov, Benjamin Greenbaum,Gustavo Palacios, W. Ian Lipkin et al (5 authors)

The origin of the current 2009 H1N1 virus has been traced to Swine herds which were not sampled for virus.


H1N1 2009 pandemic flu vaccination campaign: The Homeless lesson
By Philippe BROUQUI, Jean-Christophe LAGIER,nadim CASSIR, Sékéné BADIAGA et al (5 authors)

Sustained efforts to reach homeless population in Marseille achieved 47% vaccination rates vs about 10% in the general population.


The incidence of the H1N1 in this French island was 12.5% of the population, this served as a model for the French public health authorities for the mainland.

Optimal Pandemic Influenza Vaccine Allocation Strategies for the Canadian Population
By Ashleigh Tuite, David N. Fisman, Jeffrey C. Kwong, and Amy Greer

Prioritize the influenza H1N1 vaccine to reduce disease related morbidity and mortality in Canada. Recommend vaccine first for the high risk groups followed by age wise high risk segments. Benefits depends on the disease progression and spread.

Seasonal Influenza Vaccine Allocation in the Canadian Population during a Pandemic
By Ashleigh Tuite, David N. Fisman, Jeffrey C. Kwong, and Amy Greer

Allocation of seasonal influenza vaccine for the elderly >65 years resulted in reduced mortality and morbidity in spite of risk of co infection with H1N1 strain in Canada.


Efficient simulation of the spatial transmission dynamics of influenza
By Meng-Tsung Tsai, Tsurng-Chen Chern, Jen-Hsiang Chuang, Chih-Wen Hsueh et al (11 authors)

Authors claim that their model (unlike other models) does not over predict the spread of H1N1 pandemic and have applied it to the Taiwan population.
Symptomatic infections less frequent with H1N1pdm than with seasonal strains
By Antoine FLAHAULT, Xavier de Lamballerie,Thomas Hanslik, and nicolas salez

Prof Flahault and his team have estimated that about 20% of the French population consulted their General Practitioners due to 2009 H1N1 infections. The number of young persons (20-39 yrs) infected with Pandemic influenza was 1.7 million (range 1.1 - 2.3 million).

Epidemiological characteristics and low case fatality rate of pandemic (H1N1) 2009 in Japan
By Taro Kamigaki and Hitoshi Oshitani

Younger children were most susceptible to 2009 H1N1 infections and the mortality was lower with 85 deaths. School closing resulted in lower mortality and reduced its transmission in Japan

Absolute Humidity and the Seasonal Onset of Influenza in the Continental US
By Jeffrey Shaman, Virginia Pitzer, Cecile Viboud,Marc Lipsitch et al (5 authors)

PLoS Currents top 2 authors with most impact provide good evidence that the seasonal variations of influenza transmission in temperate regions is driven by absolute humidity. 

Is a Mass Immunization Program for Pandemic (H1N1) 2009 Good Value for Money? Early Evidence from the Canadian Experi...
By Beate Sander, Chris Bauch, David N.. Fisman, R 

One more study to justify the cost effectiveness of mass vaccination program for influenza.

Studies needed to address public health challenges of the 2009 H1N1 influenza pandemic: insights from modeling
By Maria Van Kerkhove, Neil Ferguson and Steven Riley

Authors suggest studies that will generate data not otherwise available from routine surveillance. Serological surveys stand out as a critical source of data and monitoring the time course of incidence of severe H1N1pdm cases, variability in underlying transmissibility of the virus, population behavior such as school vacations and other non-pharmaceutical interventions and alternative ways to collect data for the 2009 (and beyond) influenza H1N1 pandemic in low resource settings. 


We hope that these resources are used to monitor Current Ignored or forgotten Pandemics in tropical and poor developing countries and provide real solutions and means to combat killer diseases and reduce overall disease burden.



Authors using a mathematics model recommend prioritization vaccination of school children and young adults to stop the spread of the disease and its progression.


Once again a model based approach to predict rates of influenza co-infections like pneumonia and the need for additional stockpiling of antibiotics.
1. H1N1 vaccination and adults with underlying health conditions in the US
By Edward Goldstein and Marc Lipsitch make a strong case for the inclusion of adults with underlying diseases in the high priority groups for H1N1 vaccination. These patients accounted for 65% of the 4000 deaths recorded in the US.

2. The Early Transmission Dynamics of H1N1pdm Influenza in the United Kingdom
By Azra Ghani, Marc Baguelin, Jamie Griffin,Stefan Flasche et al (18 authors)
Ghani et al show that candy like widespread distribution of Tamiflu for treatment and prophylaxis reduced transmission rates by 16%.

3.  Estimate of Novel Influenza A/H1N1 cases in Mexico at the early stage of the pandemic with a spatially structured epi...
By Vittoria Colizza, Alessandro Vespignani, Nicola Perra, Chiara Poletto et al (12 authors)
Due to the absence of confirmatory tests, indirect model of H1N1 pandemic in Mexico ranged from 120000 to 1.4 million cases.

4. Public preparedness guidance for a severe influenza pandemic in different countries: a qualitative assessment...
By Wladimir J. Alonso and Dr. Cynthia Schuck Paim
The divergence of official guideline in different countries has been presented. Developing countries follow WHO guidelines but european and OECD countries have their own health systems which diverge in different ways. Although H1N1 does nor stop at borders, government directives to population during Pandemic emergency differ in advanced countries
5. Optimizing Tactics for use of the U.S. Antiviral Strategic National Stockpile for Pandemic (H1N1) Influenza, 2009
By Nedialko Dimitrov, Sebastian Goll, Lauren Ancel Meyers, Babak Pourbohloul et al (5 authors) 
Authors have prposed wider use of antiviral drugs like Tamiflu and Relenza. The higher cost and the risk of new emergent drug resistant strains was not discussed.

6. Quantifying the transmissibility of human influenza and its seasonal variation in temperate regions
Authors estimate that the differences in number of infected persons during high and low influenza season varies by only 5-10%. The immunity acquired through annual vaccination against the currently circulating influenza strains wanes after 4 - 8 years. 
7. Mining the NCBI Influenza Sequence Database: adaptive grouping of BLAST results using precalculated neighbor indexing
The Influenza Virus Resource and other Virus Variation Resources at NCBI provide enhanced visualization web tools. A new BLAST-based algorithm has been developed for virus sequence data mining and is being integrated with the NCBI Influenza sources.

A vaccine for pigs to protect them was developed by a team from Harris Vaccine. Vaccinated pigs had higher antibody response, reduce viral shedding and better weight gain in comparison with the non vaccinated animals.
9. Improving the diagnostic efficiency of H1N1 2009 pandemic flu: analysis of predictive clinical signs through a prospe...
By Philippe BROUQUI, Vinh VU HAI, Antoine NOUGAIREDE, Jean-Christophe LAGIER et al (10 authors)
Confirmatory tests for 2009 H1N1 should be limited to the hospitalized patients and patient groups at risk, to keep down the cost of diagnostic testing. This paper merits 5 star rating.

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10. Can Reactive School Closures help critical care provision during the current influenza pandemic?
By Thomas House, Marc Baguelin, Albert Jan van Hoek, Stefan Flasche et al (11 authors)
Using mathematical models, the authors conclude that school closings in Western nations is unlikely to limit the spread of 2009 H1N1 pandemic.

Archieves
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8. Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase
By Takashi Kuzuhara, Yuma Iwai, Hironobu Takahashi, Dai Hatakeyama et al (5 authors)
The influenza A RNA polymerase possesses endonuclease activity to digest the host mRNA. This has been used to measure antiviral activity of green tea extract and can be used to discover new drugs with a different mode of action.

Remove
9. Economic Cost and Health Care Workforce Effects of School Closures in the U.S.
By Howard Lempel, Joshua M Epstein and Ross A Hammond
School closure is an important component of U.S. pandemic flu mitigation strategy, but has important costs. The authors arrive at a cost estimate between $10 and $47 billion for 4 weeks of school closure in the U.S. These models have high error rate. The authors should provide a comparative prior estimate with the current situation. We are surprised that this paper was accepted by PLoS Currents while antiviral market data is not considered suitable for the journal.

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10. The Shifting Demographic Landscape of Influenza
By Shweta Bansal, Babak Pourbohloul, Nathaniel Hupert, Bryan Grenfell et al (5 authors)
As Pandemic (H1N1) 2009 influenza spreads around the globe, it strikes school-age children more often than other age groups. This is an important paper from the CDC. 5 star rating. A must read for all parents.

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11. Pandemic influenza dynamics and the breakdown of herd immunity
By Guy Katriel and Lewi Stone
Attempts have been made to derive forecasts using a mathematical model for the ongoing H1N1 pandemic. Difficult to judge the validity in current pandemic.

Remove
12. E14-F55 combination in M2 protein: a putative molecular determinant responsible for swine-origin influenza A virus
By Chungen Pan and Shibo Jiang
The authors have identified a highly conserved region in the m2 protein of the human virus strains of influenza which may serve as a new target for development of new vaccines, immunoprpphylaxis or antiviral therapy. Important contribution, 5 star rating.

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13. The severity of pandemic H1N1 influenza in the United States, April – July 2009
By Anne M Presanis, Marc Lipsitch, Daniela De Angelis, Swine Flu Investigation Team, New York City Department of Health and Mental Hygiene et al (10 authors)
Once again, an important contribution from the group to measure the impact and mortality of the current influenza pandemic. 5 star rating

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14. SeqMonitor: Influenza Analysis Pipeline and Visualization
By Norman MacDonald, Donovan Parks and Robert Beiko
Unprecedented sequencing effort has led to daily submissions of influenza genomes to public repositories such as the NCBI and PubMed. Important contribution and it merits a 5 star rating.
Remove15. Behavioural responses to influenza pandemics
The authors have reviewed the public health, authorities and population response to past pandemic outbreaks. In the past due to absence of any treatment, public awareness, rapid communication and simple measures of hygiene like hand washing, protective mask and isolation were effective. This is a retrospective literature search and analysis study.
16. Social versus independent interest in 'bird flu' and 'swine flu' 
The authors have taken an obvious public/reader's transient short term and fluctuating interest in H1N1, through SE and Google trends to make it more complicated and given it a mathematical/statistical treatment with difficult to understand equations. There was a sharp drop in the searches for Swine flu (comparable to Bird flu incidence) in Western Europe and the U.S. Our readers can observe the same effect by comparing the weekly or daily  PVs of H1N1 News, Pandemic Review and PLoS Currents - Influenza to observe a 60-70% decline in PVs since the launch of PLoS.

17. Adjuvant is necessary for a robust immune response to a single dose of H1N1 pandemic flu vaccine in mice

Novartis scientists present preclinical evidence for the increased efficacy of the cell cultured Pandemic Swine Flu vaccine with Mf59 adjuvant which may require only 1 injection if confirmed in currently ongoing clinical trials. Glaxo Smith Kline new Pandemic flu vaccine in clinical trials uses another adjuvant.
MS adds: an "adjuvant" improves our body's immune system response to a vaccine. A successful adjuvant thus enables a smaller volume or dose of vaccine to achieve the desired protection.

18. First estimation of direct H1N1pdm virulence

An analysis of 100K geographically restricted cases enables the authors to project direct lethality of 1 in 10,000 cases. The CDC estimate based on U.S. data was 1.48. If the additional two deaths in New Caledonia are counted, the estimate will be higher. The mortality risk increases for pregnant women, the obese and persons with other chronic conditions. If these projections are right then H1N1 global toll may reach 700 000.

19. Fitness of Pandemic H1N1 and Seasonal influenza A viruses during Co-infection

Research shows that the current swine flu virus (H1N1) is more competitive (transmissible) and has a biologic advantage over other likely seasonal flu viruses this year. However, the authors issue a call for further investigation due to known issues with their "ferret" model.

20. Molecular modeling of swine influenza A/H1N1, Spanish H1N1, and avian H5N1 flu N1 neuraminidases bound to Tamiflu and...
Computer-based molecular modeling of the antiviral binding site provides tools to speed the design of new antiviral drugs in the event of virus mutation.

The World Health Organization has raised the A/H1N1 pandemic alert level to 6, its highest level.  A thorough understanding of this type of virus in all aspects (transmission, protection, vaccine, drug binding) is therefore important to increase our degree of preparedness.
 
KM has done a review of this knol, given it a 5 star rating and left a comment to which the authors have responded. An image has been copied into Swine Flu pandemic review.

21. Mortality and morbidity burden associated with A/H1N1pdm influenza virus

This study deals with the questions: Who is likely to be infected; and what is the expected death rate? The authors extrapolate different evolutions of virus spreading and mortality rates for developed countries with health care facilities vs. poor countries with lack of facilities. Conclusion: All methods of data projection have large errors; all projections must be considered in the context of best case and worst case scenarios.


22. Next Generation Syndromic Surveillance
Recommends the use of electronic health records to track confirmed cases of infection and clinical outcome.

23. Promising Antiviral Drugs for Swine flu A/H1N1 Revealed by Virtual Screening

The team of Prof Thanh Truong has now revealed 6 promising leads from the NCI database which are more effective than existing drugs.
Readers are reminded that drug development is a long and costly process, may take 7-12 years, cost over $1 billion. Most early leads fail to pass safety and efficacy criteria. We need many more leads and development projects to discover the next safe and effective antiviral. KM left a comment and ranked it 5 stars.

24.  Reassortment Patterns in Swine Influenza Viruses

Authors employ statistics to accurately pinpoint the source and infection modes of H1N1 influenza, concluding that the virus is capable of rapid change, thus increasing its danger to humans. Understanding these mechanisms help scientists develop countermeasures:
The reassortment patterns in swine viruses confirm previous results found in human viruses that the glycoprotein coding segments reassort most often. Moreover, one of the polymerase segments (PB1), reassorted in the strains responsible for the last two human pandemics of 1957 and 1968, also reassorts frequently.

25.  Reconstructing the initial global spread of a human influenza pandemic
The evolution and spread of the Pandemic flu is tracked by viral genetic data across the globe, backed up by detailed maps and video, the first video link in a PLoS knol

26. Spatiotemporal dynamics in the early stages of the 2009 A/H1N1 influenza pandemic

Sequence analysis of H1N1 strains shows the prominence of the east-west routes of infection as if it was straight out ofProf Jared Diamond's book Guns, Germs and Steel and may explain why central African countries have lower incidence of H1N1 deaths.

27. Swine origin influenza A (H1N1) virus and ICU capacity in the US. Are we prepared?

Authors employed computer simulations to predict impact of H1N1 in the United States, concluding:
We calculate that 46 million people will contract the infection, resulting in 2.7 million hospitalizations, 331,587 episodes of ARF-MV and nearly 200,000 deaths...



The current knol serves as a reference for the following knols on the subject






















Influenza A ( 2009 H1N1 ) Original Articles

  1. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team , Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans , Published at www.nejm.org May 7, 2009 (10.1056/NEJMoa0903810).
  2. Fraser,C,  Donnelly,CA, Cauchemez,S.  Hanage,WP. Maria D. et al and The WHO Rapid Pandemic Assessment Collaboration. Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings. Science Express 11 may 2009, Science 324, 1557-1561, 2009. Doi: 10.1126/science.1176062.
  3. Garten RJ, Davis CT. , Colin A. Russell CA., et al.  Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans. Published Online May 22, 2009. Science DOI: 10.1126/science.1176225.
  4. Dharan,NJ; Gubareva, LV; Meyer, JJ et al; for the Oseltamivir-Resistance Working Group. Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States. JAMA. 2009;301(10):1034-1041. Published online March 2, 2009 (doi:10.1001/jama.2009.294).
  5.  David M. Morens, M.D., Jeffery K. Taubenberger, Anthony S. Fauci. The Persistent Legacy of the 1918 Influenza Virus. N Engl J Med 361: 225-229, 2009. Published Online June 29, 2009 (DOI: 10.1056/NEJMp0904819).
  6. Brownstein JS, Freifeld CC, Madoff LC. Influenza A (H1N1) Virus, 2009 — Online Monitoring.       N Engl J Med 360:2156, May 21, 2009. (DOI: 10.1056/NEJMp09040.
  7. Marc Lipsitch, Steven Riley, Simon Cauchemez, Azra C. Ghani, and Neil M. Ferguson. Managing   and Reducing Uncertainty in an Emerging Influenza Pandemic. N Engl J Med. 361, 112-115, 2009.   (DOI: 10.1056/NEJMp0904380).
  8. Vladimir Trifonov, Hossein Khiabanian, and Raul Rabadan. Geographic Dependence, Surveillance,  and Origins of the 2009 Influenza A (H1N1) Virus. N Engl J Med. 361, 115-119, 2009. (DOI: 10.1056/NEJMp0904572).
  9. Zimmer, S. M. Burke, D. S. Historical Perspectives-Emergence of influenza A viruses. N Eng J Med. 361, 279-285, 2009. (DOI: 10.1056/NEJMp0904322).
  10. Perez-Padilla, R., Rosa- Zamboni, D, Leon, S.P., Hernendez, M. et al. Pneumonia and respiratory Failure from Swine origin Influenza A (H1N1) in Mexico. N Engl J Med 361, 1-10, 2009. (DOI: 10.1056/NEJMp0904252).
  11. Chowell, G, Bertozzi, S, Colchero, MA, Gatell, HL et al. Severe Respiratory disease concurrent with the circulation of H1N1 Influenza. N Engl J Med. 361, 1-6, 2009.  (DOI: 10.1056/NEJMp0904023).
  12. Manzoli, L., Salanti G., Vito CD, Boccia, A., Ionnidis JPA, Villari, P. Immunogenicity and adverse events of avian influenza A H5N1 vaccine in healthy adults: multiple-treatments meta-analysis. The Lancet Infectious Diseases, 9, 482-492, 2009.
  13. Kunisaki KM, Janoff  EN. Influenza in immunosuppressed populations: a review of infection frequency, morbidity, mortality, and vaccine responses. The Lancet Infectious Diseases, 9, 493-504, 2009.
  14. Vivek Shinde, et al. , Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009 - Published at www.nejm.org May 7, 2009 (10.1056/NEJMoa0903812).
  16. Neumann, G., Noda, T.,  Kawaoka, Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459, 931-939 (14 June 2009) doi:10.1038/nature08157.
  17. Gostin, LA. Influenza A(H1N1) and Pandemic Preparedness Under the Rule of International Law . JAMA,  2009; 301: 2376 - 2378.
  18. Tanaka, T. Nakajima, K. Murashima, A. Garcia-Bournissen, F.  Koren, G.  Ito, S. Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women. Can. Med. Assoc. J., Jul 2009; 181: 55 - 58 ; doi:10.1503/cmaj.090866
  19. Jamieson DJ, Honein MA, Rasmussen SA, Williams JL, Swerdlow DL, Biggerstaff MS, Lindstrom S, Janice K Louie, Cara M Christ, Susan R Bohm, Vincent P Fonseca, Kathleen A Ritger, Daniel J Kuhles, Paula Eggers, Hollianne Bruce, Heidi A Davidson, Emily Lutterloh, Meghan L Harris , Colleen Burke, Noelle Cocoros, Lyn Finelli, Kitty F MacFarlane, Bo Shu, Sonja J Olsen, the Novel Influenza A (H1N1) Pregnancy Working Group, CDC.
     H1N1 2009 influenza virus infection during pregnancy in the USA. The Lancet, Early Online Publication, 29 July 2009 . doi:10.1016/S0140-6736(09)61304-0
    Pregnant women were at higher risk for complications from infection with Influenza A (H1N1)v virus in comparison with general population. The study supports the recommendation of the CDC expert panel to promptly treat infected pregnant women with antiviral drugs and vaccinate pregnant women as the high priority group ahead of healthcare workers.
  20. Thanyada Rungrotmongkol, Pathumwadee Intharathep , Maturos Malaisree a, Nadtanet Nunthaboot c,
    Nopphorn Kaiyawet a, Pornthep Sompornpisut a, Sanchai Payungporn d, Yong Poovorawan,Supot Hannongbua. Susceptibility of antiviral drugs against 2009 influenza A (H1N1) virus. Biochemical and Biophysical Research Communications 385 (2009) 390–394.
  21. J.S. Malik Peiris, Leo L.M. Poona, Yi Guana. Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans. Journal of Clinical Virology 45 (2009) 169–173.
  22. Christine C. Ginocchioa,∗, Frank Zhanga, Ryhana Manjia, Suman Aroraa, Mark Bornfreunda,
    Leon Falka, Madhavi Lotlikar a, Margaret Kowerskaa, George Becker a, Diamanto Korologosa, Marcella de Geronimob, James M. Crawford. Evaluation of multiple test methods for the detection of the novel 2009
    influenza A (H1N1) during the New York City outbreak. Journal of Clinical Virology 45 (2009) 191–195.
  23.  Derek Gatherer. The 2009 H1N1 influenza outbreak in its historical context. Journal of Clinical Virology 45 (2009) 174–178.
  24. Marla Laya , Bernadette Callejo a , Stella Changa , David K. Hongb , David B. Lewisb , Timothy D. Carroll c ,Shannon Matzingerc, Linda Fritts c, Christopher J. Millerc, John F.Warnera, Lily Lianga, Jeffery Fairman. Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone®) increases antibody response, cellular immunity, and antigenically drifted protection. Vaccine 27 (2009) 3811–382 .
  25. Shu-Qing Wang, Qi-Shi Du, Ri-Bo Huang, Da-Wei Zhang, Kuo-Chen Chou. Insights from investigating the interaction of oseltamivir (Tamiflu) with neuraminidase of the 2009 H1N1 swine flu virus. Biochemical and Biophysical Research Communications xxx (2009) xxx–xxx.
  26. Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses
    in Oceania, South East Asia and South Africa. Aeron C. Hurta,b,∗, Joanne Ernest a, Yi-Mo Denga, Pina Iannelloa, Terry G. Besselaarc, Chris Birchd, Philippe Buchye, Malinee Chittaganpitchf, Shu-Chun Chiug, Dominic Dwyerh, Aurélie Guigoni, Bruce Harrower j, Ip Peng Keik, Tuckweng Kokl, Cui Linm, Ken McPhieh, Apandi Mohdn, Remigio Olvedao, Tony Panayotoup,William Rawlinsonq, Lesley Scott r, David Smiths, Holly D’Souzat, Naomi Komadinaa, Robert Shawa, Anne Kelsoa, Ian G. Barra,b Antiviral Research 83 (2009) 90–93.
  27. Noni MacDonald, Paul C Hébert, Matthew B Stanbrook, Ken Flegel, Amir Attaran, and Laura Eggertson. H1N1 influenza vaccine: global access for a global problem.
    Can. Med. Assoc. J., Jun 2009; doi:10.1503/cmaj.091100.
  28. Paul Webster. Infectious disease experts expect the unexpected with respect to swine flu.
    Can. Med. Assoc. J., Jul 2009; doi:10.1503/cmaj.091176.
  29. Shun-Shin, M. Thompson, M. Heneghan, C. Perera, R. Anthony Harnden, A. Mant, D.
    Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials. Published 10 August 2009, doi:10.1136/bmj.b3172. BMJ 2009;339:b3172.
    Open Access article: http://www.bmj.com/cgi/content/abstract/339/aug10_1/b317
  30. Catherine W M Ong, Khek Yu Ho, Li Yang Hsu,Aymeric Y T Lim, Dale A Fisher, Paul A Tambyah
Reacting to the emergence of swine-origin infl uenza A H1N1. www.thelancet.com/infection Vol 9 July 2009.
31. Evans, D, Cauchemez, S, Hayden, FG. "Prepandemic" immunization for novel influenza viruses, "swine flu" vaccine, guillain-barre syndrome, and the detection of rare severe adverse events. J Infect Dis 2009; 200:321.
Gerardo Chowell, Cecile Viboud, Xiaohong Wang, Stefano Bertozzi, and Mark Miller
PLoS Currents: Influenza. 2009 August 19:RRN1004.
Andrew Rambaut and Edward Holmes
PLoS Currents: Influenza. 2009 August 18:RRN1003.
Joshua L. Cherry, David J. Lipman, Anastasia Nikolskaya, and Yuri I Wolf
PLoS Currents: Influenza. 2009 August 18:RRN1001.
Melissa Sweet. Pandemic lessons from Australia. Published 18 August 2009, doi:10.1136/bmj.b3317. BMJ 2009;339:b3317.
36. Patient-oriented pandemic influenza research
The Lancet, Volume 373, Issue 9681, 20 June 2009-26 June 2009, Pages 2085-2086
Tran Tinh Hien, Guillermo M Ruiz-Palacios, Frederick G Hayden, Jeremy Farrar

37. April 2009: an outbreak of swine-origin influenza A(H1N1) virus with evidence for human-to-human transmission
Microbes and Infection, Volume 11, Issues 8-9, July-August 2009, Pages 725-728
Nadia Naffakh, Sylvie van der Werf

38. Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin
Vaccine, In Press, Corrected Proof, Available online 3 August 2009
Langzhou Song, Yi Zhang, Nadezhda E. Yun, Allison L. Poussard, Jeanon N. Smith, Jennifer K. Smith, Viktoriya Borisevich, Jenna J. Linde, Michele A. Zacks, Hong Li, Uma Kavita, Lucia Reiserova, Xiangyu Liu, Kunmi Dumuren, Bhuvaneswari Balasubramanian, Bruce Weaver, Jason Parent, Scott Umlauf, Ge Liu, Jim Huleatt, et al.

39. The Influenza Virus Enigma
Cell, Volume 136, Issue 3, 6 February 2009, Pages 402-410
Rachelle Salomon, Robert G. Webster
40. Severe Respiratory Disease Concurrent with the Circulation of H1N1 Influenza
Gerardo Chowell, Ph.D., Stefano M. Bertozzi, M.D., Ph.D., M. Arantxa Colchero, Ph.D., Hugo Lopez-Gatell, M.D., Ph.D., Celia Alpuche-Aranda, M.D., Ph.D., Mauricio Hernandez, M.D., Ph.D., and Mark A. Miller, M.D. NEJM 361 (7), 674-679, 2009.
41. Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
Rogelio Perez-Padilla, M.D., Daniela de la Rosa-Zamboni, M.D., Samuel Ponce de Leon, M.D., Mauricio Hernandez, M.D., Francisco Quiñones-Falconi, M.D., Edgar Bautista, M.D., Alejandra Ramirez-Venegas, M.D., Jorge Rojas-Serrano, M.D., Christopher E. Ormsby, M.Sc., Ariel Corrales, M.D., Anjarath Higuera, M.D., Edgar Mondragon, M.D., Jose Angel Cordova-Villalobos, M.D., for the INER Working Group on Influenza. NEJM 361(7), 680-689, 2009.  
42. Toshihiro Tanaka, Ken Nakajima, Atsuko Murashima, Facundo Garcia-Bournissen, Gideon Koren, and Shinya Ito
Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women
Can. Med. Assoc. J., Jul 2009; 181: 55 - 58 ; doi:10.1503/cmaj.090866.


  • Newest H1N1 influenza sequences



  • Submit flu sequences to GenBank



  • Latest H1N1 citations in PubMed




    • Results: 1 to 20 of 1344

    1.
    Subtype identification of the novel A H1N1 and other human influenza A viruses using an oligonucleotide microarray.
    Kang X, Li Y, Sun H, Wu W, Liu H, Lin F, Qing C, Chang G, Zhu Q, Chen W, Yang Y.
    Arch Virol. 2009 Dec 10. [Epub ahead of print]PMID: 19998047 [PubMed - as supplied by publisher]Related articles
    2.
    The macroeconomic impact of pandemic influenza: estimates from models of the United Kingdom, France, Belgium and The Netherlands.
    Keogh-Brown MR, Smith RD, Edmunds JW, Beutels P.
    Eur J Health Econ. 2009 Dec 9. [Epub ahead of print]PMID: 19997956 [PubMed - as supplied by publisher]Related articles
    3.
    Hepatitis E Virus Infection in Central China Reveals No Evidence of Cross-Species Transmission between Human and Swine in This Area.
    Zhang W, Yang S, Ren L, Shen Q, Cui L, Fan K, Huang F, Kang Y, Shan T, Wei J, Xiu H, Lou Y, Liu J, Yang Z, Zhu J, Hua X.
    PLoS One. 2009 Dec 7;4(12):e8156.PMID: 19997619 [PubMed - in process]Free article
    4.
    The severity of pandemic H1N1 influenza in the United States, from April to July 2009: a Bayesian analysis.
    Presanis AM, De Angelis D; New York City Swine Flu Investigation Team, Hagy A, Reed C, Riley S, Cooper BS, Finelli L, Biedrzycki P, Lipsitch M.
    PLoS Med. 2009 Dec;6(12):e1000207. Epub 2009 Dec 8.PMID: 19997612 [PubMed - in process]Related articlesFree article
    5.
    Adaptive vaccination strategies to mitigate pandemic influenza: Mexico as a case study.
    Chowell G, Viboud C, Wang X, Bertozzi SM, Miller MA.
    PLoS One. 2009 Dec 3;4(12):e8164.PMID: 19997603 [PubMed - in process]Free article
    6.
    Early assessment of anxiety and behavioral response to novel swine-origin influenza A(H1N1).
    Jones JH, Salathé M.
    PLoS One. 2009 Dec 3;4(12):e8032.PMID: 19997505 [PubMed - in process]Free article
    7.
    Direct multiplex reverse transcription-nested PCR detection of influenza viruses without RNA purification.
    Song MK, Chang J, Hong Y, Hong S, Kim SW.
    J Microbiol Biotechnol. 2009 Nov;19(11):1470-4.PMID: 19996703 [PubMed - in process]Related articlesFree article
    8.
    Adaptive strategies of the influenza virus polymerase for replication in humans.
    Mehle A, Doudna JA.
    Proc Natl Acad Sci U S A. 2009 Dec 7. [Epub ahead of print]PMID: 19995968 [PubMed - as supplied by publisher]Related articlesFree article
    9.
    Short Communication: Diagnostic performance of rapid influenza antigen assays in patients infected with the new influenza A (H1N1) virus.
    Herzum I, Lutz T, Koch F, Geisel R, Gehrt A.
    Clin Chem Lab Med. 2009 Dec 8. [Epub ahead of print]PMID: 19995180 [PubMed - as supplied by publisher]Related articles
    10.
    Rapid diagnosis of swine-origin influenza A (H1N1) virus (S-OIV): useful or hype?
    Lippi G, Plebani M.
    Clin Chem Lab Med. 2009 Dec 8. [Epub ahead of print] No abstract available.PMID: 19995179 [PubMed - as supplied by publisher]Related articles
    11.
    Pandemic influenza (H1N1): our Canadian response.
    Spika JS, Butler-Jones D.
    Can J Public Health. 2009 Sep-Oct;100(5):337-9.PMID: 19994732 [PubMed - in process]Related articles
    13.
    Fall in swine flu cases may not signal an end of the epidemic, warns Professor Donaldson.
    Mashta O.
    BMJ. 2009 Dec 7;339:b5329. doi: 10.1136/bmj.b5329. No abstract available.PMID: 19969608 [PubMed - in process]
    14.
    Porcine reproductive and respiratory syndrome virus attachment is mediated by the N-terminal domain of the sialoadhesin receptor.
    An TQ, Tian ZJ, He YX, Xiao Y, Jiang YF, Peng JM, Zhou YJ, Liu D, Tong GZ.
    Vet Microbiol. 2009 Dec 5. [Epub ahead of print]PMID: 19969429 [PubMed - as supplied by publisher]Related articles
    15.
    Exposure to MF59-adjuvanted influenza vaccines during pregnancy-A retrospective analysis.
    Tsai T, Kyaw MH, Novicki D, Nacci P, Rai S, Clemens R.
    Vaccine. 2009 Dec 4. [Epub ahead of print]PMID: 19969117 [PubMed - as supplied by publisher]Related articles
    17.
    H1N1 influenza: contact investigation burden because of failure to institute influenza precautions in patients with negative rapid influenza diagnostic test results.
    Cunha BA, Thekkel V, Cohan C.
    Infect Control Hosp Epidemiol. 2010 Jan;31(1):102-4. No abstract available.PMID: 19968491 [PubMed - in process]Related articles
    18.
    African swine fever.
    Penrith ML.
    Onderstepoort J Vet Res. 2009 Mar;76(1):91-5.PMID: 19967933 [PubMed - in process]Related articles
    19.
    Coding for the H1N1 virus vaccination.
    Martin V.
    Med Econ. 2009 Oct 23;86(20):26. No abstract available.PMID: 19967852 [PubMed - in process]Related articles
    20.
    Nurses, the 2009 h1n1 flu, and seasonal vaccination.
    Aschenbrenner DS.
    Am J Nurs. 2009 Dec;109(12):56-9. No abstract available.PMID: 19966679 [PubMed - in process]Related articles


    Results: 1 to 20 of 1347

    1.
    Differentiation of two distinct clusters among currently circulating influenza A(H1N1)v viruses, March-September 2009.
    Fereidouni S, Beer M, Vahlenkamp T, Starick E.
    Euro Surveill. 2009 Nov 19;14(46). pii: 19409.PMID: 19941799 [PubMed - as supplied by publisher]
    2.
    Oseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses.
    Ciancio B, Meerhoff T, Kramarz P, Bonmarin I, Borgen K, Boucher C, Buchholz U, Buda S, Dijkstra F, Dudman S, Duwe S, Hauge S, Hungnes O, Meijer A, Mossong J, Paget W, Phin N, van der Sande M, Schweiger B, Nicoll A.
    Euro Surveill. 2009 Nov 19;14(46). pii: 19412. No abstract available.PMID: 19941797 [PubMed - as supplied by publisher]
    3.
    A simple mathematical approach to deciding the dosage of vaccine against pandemic H1N1 influenza.
    Nishiura H, Iwata K.
    Euro Surveill. 2009 Nov 12;14(45). pii: 19396.PMID: 19941790 [PubMed - as supplied by publisher]
    4.
    Pandemic influenza A(H1N1)v: Human to pig transmission in Norway?
    Hofshagen M, Gjerset B, Er C, Tarpai A, Brun E, Dannevig B, Bruheim T, Fostad I, Iversen B, Hungnes O, Lium B.
    Euro Surveill. 2009 Nov 12;14(45). pii: 19406.PMID: 19941789 [PubMed - as supplied by publisher]
    5.
    Assessing the impact of the 2009 H1N1 influenza pandemic on reporting of other threats through the Early Warning and Response System.
    Cox A, Guglielmetti P, Coulombier D.
    Euro Surveill. 2009 Nov 12;14(45). pii: 19397.PMID: 19941788 [PubMed - as supplied by publisher]
    6.
    Syndromic surveillance: the next phase of public health monitoring during the H1N1 influenza pandemic?
    Elliot A.
    Euro Surveill. 2009 Nov 5;14(44). pii: 19391. No abstract available.PMID: 19941780 [PubMed - as supplied by publisher]
    7.
    Surveillance of the first 205 confirmed hospitalised cases of pandemic H1N1 influenza in Ireland, 28 April - 3 October 2009.
    Cullen G, Martin J, O Donnell J, Boland M, Canny M, Keane E, McNamara A, O Hora A, Fitzgerald M, Jackson S, Igoe D, O Flanagan D.
    Euro Surveill. 2009 Nov 5;14(44). pii: 19389.PMID: 19941779 [PubMed - as supplied by publisher]
    8.
    Measures against transmission of pandemic H1N1 influenza in Japan in 2009: simulation model.
    Yasuda H, Suzuki K.
    Euro Surveill. 2009 Nov 5;14(44). pii: 19385.PMID: 19941778 [PubMed - as supplied by publisher]
    9.
    Interpreting Google Flu Trends data for pandemic H1N1 influenza: The New Zealand experience.
    Wilson N, Mason K, Tobias M, Peacey M, Huang Q, Baker M.
    Euro Surveill. 2009 Nov 5;14(44). pii: 19386.PMID: 19941777 [PubMed - as supplied by publisher]
    10.
    I-MOVE towards monitoring seasonal and pandemic influenza vaccine effectiveness: lessons learnt from a pilot multi-centric case-control study in Europe, 2008-9.
    Kissling E, Valenciano M, Falcao J, Larrauri A, Widgren K, Pitigoi D, Oroszi B, Nunes B, Savulescu C, Mazick A, Lupulescu E, Ciancio B, Moren A.
    Euro Surveill. 2009 Nov 5;14(44). pii: 19388.PMID: 19941774 [PubMed - as supplied by publisher]
    11.
    Rhinoviruses, A(H1N1)v, RVS: The race for hivernal pandemics, France 2009-2010.
    Casalegno J, Bouscambert-Duchamp M, Morfin F, Lina B, Escuret V.
    Euro Surveill. 2009 Nov 5;14(44). pii: 19390. No abstract available.PMID: 19941772 [PubMed - as supplied by publisher]
    12.
    A host species-informative internal control for molecular assessment of African swine fever virus infection rates in the African sylvatic cycle Ornithodoros vector.
    Bastos AD, Arnot LF, Jacquier MD, Maree S.
    Med Vet Entomol. 2009 Dec;23(4):399-409.PMID: 19941606 [PubMed - as supplied by publisher]
    13.
    Antigens containing TAVSPTTLR tandem repeats could be used in assaying antibodies to Classical swine fever virus.
    Qi Y, Zhang BQ, Shen Z, Chen YH.
    Acta Virol. 2009;53(4):241-246.PMID: 19941387 [PubMed - as supplied by publisher]
    14.
    A case of ARDS associated with influenza A - H1N1 infection treated with extracorporeal respiratory support.
    Grasselli G, Foti G, Patroniti N, Giuffrida A, Cortinovis B, Zanella A, Pagni F, Mergoni M, Pesci A, Pesenti A.
    Minerva Anestesiol. 2009 Dec;75(12):741-5.PMID: 19940827 [PubMed - in process]
    15.
    Novel H1N1 Virus Infection and Pregnancy.
    Satpathy HK, Lindsay M, Kawwass JF.
    Postgrad Med. 2009 Nov;121(6):106-12.PMID: 19940421 [PubMed - in process]
    16.
    Higher Pneumococcal Disease Vaccination Rates Needed to Protect More At-Risk US Adults.
    Rehm SJ, Farley MM, File TM Jr, Hall WJ, Hopkins R, Levine OS, Nichol KL, Nuorti P, Zimmerman RK, Schaffner W.
    Postgrad Med. 2009 Nov;121(6):101-5.PMID: 19940420 [PubMed - in process]
    17.
    The Emotional Epidemiology of H1N1 Influenza Vaccination.
    Ofri D.
    N Engl J Med. 2009 Nov 25. [Epub ahead of print] No abstract available.PMID: 19940291 [PubMed - as supplied by publisher]
    18.
    When to Consider the Use of Antibiotics in the Treatment of 2009 H1N1 Influenza-Associated Pneumonia.
    Wright PF, Kirkland KB, Modlin JF.
    N Engl J Med. 2009 Nov 25. [Epub ahead of print] No abstract available.PMID: 19940288 [PubMed - as supplied by publisher]
    19.
    Australia's Winter with the 2009 Pandemic Influenza A (H1N1) Virus.
    Bishop JF, Murnane MP, Owen R.
    N Engl J Med. 2009 Nov 25. [Epub ahead of print] No abstract available.PMID: 19940287 [PubMed - as supplied by publisher]
    20.
    Incidence, diversity and molecular epidemiology of sapoviruses in swine across Europe.
    Reuter G, Zimsek-Mijovski J, Poljsak-Prijatelj M, Di Bartolo I, Ruggeri FM, Kantala T, Maunula L, Kiss I, Kecskeméti S, Halaihel N, Buesa J, Johnsen C, Hjulsager CK, Larsen LE, Koopmans M, Böttiger B.
    J Clin Microbiol. 2009 Nov 25. [Epub ahead of print]PMID: 19940055 [PubMed - as supplied by publisher]

    Low-dose arsenic compromises the immune response to influenza A infection in vivo.
    Kozul CD, Ely KH, Enelow RI, Hamilton JW.
    Environ Health Perspect. 2009 Sep;117(9):1441-7. Epub 2009 May 20.
    PMID: 19750111 [PubMed - in process]
    Related Articles
    2:
    Swine CAFOs & novel H1N1 flu: separating facts from fears.
    Schmidt CW.
    Environ Health Perspect. 2009 Sep;117(9):A394-401. No abstract available.
    PMID: 19750087 [PubMed - in process]
    Related Articles
    3:
    The swine flu, advice giving and the reporting of adverse drug reactions.
    Griffith R, Tengnah C.
    Br J Community Nurs. 2009 Sep;14(9):405-9.
    PMID: 19749660 [PubMed - in process]
    Related Articles
    4:
    Method for rapid detection of swine influenza virus.
    Maldonado J, Valls L, Riera P.
    Vet Rec. 2009 Sep 12;165(11):328. No abstract available.
    PMID: 19749213 [PubMed - in process]
    Related Articles
    5:
    Influenza A (H1N1) pandemic: true or false alarm.
    Allam MF.
    J Epidemiol Community Health. 2009 Oct;63(10):862. No abstract available.
    PMID: 19749128 [PubMed - in process]
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    6:
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    [Algebra, calculus and geometry of contagion at the early evolution of a A (H1N1) pandemic spread.]
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    Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis--North Carolina, 2009.
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    Authors Comments on some Influenza A (H1N1) Pandemic  papers and reviews
    Morens and Taubenberger 2009 in a paper in NEJM showed that the precursors of the H1N1 virus have persisted in humans for over 90 years.
    Chowell et al NEJM 2009 observed the shift in the age distribution to younger patients during early phase of this pandemic and very similar to past pandemics. Elderly patients may have some immunity due to past exposure to 1957 flu pandemic.
    Padilla et al. NEJM 2009 first reported the pneumonia and severe respiratory failure in younger patients in Mexico.
    Zimmer and Burke NEJM 2009 reviewed the emergence of flu viruses since 1918 pandemic.Trifonov et al NEJM 2009 discuss the origin of the current H1N1 virus and call for more efficient surveillance.
    In the study by Shun-Shin et al (2009), systematic review and meta analysis of four randomized double blind studies in 1766 children <12 years of age with influenza A.(2 studies with each antiviral neuraminidase inhibitors), there was small benefit (symptom reduction 0.5-1.5 days). A ten day course of postexposure prophylaxis treatment resulted in only 8% decrease in the flu incidence. The two antivirals had little or no effect on asthma exacerbations or the use of antibiotics. The effect on current H1N1v and on serious complications in children has not been studied.
     
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     Les Knols de SALIM DJELOUAT
    Krishan Maggon                                              
    Krishan Maggon Knols
    Patrick Lahaye

    Swine Flu News & Influenza Times | Grippe A (H1N1) v 2009 |Le Virus A (H1N1) v : Grippe Porcine à variante Humaine | Peramivir: Swine Flu Pandemic Emergency Use? |
     Swine Flu [Influenza A (H1N1)v] Pandemic Review
    Swine Flu Pandemic Scientific & Medical Resources

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    Thanks are due to Mr. Jean-Antoine de Mandato (PDP, Geneva) for providing office facilities and administrative support.

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